ACACA-TADA2A Fusion FISH Probe
The ACACA-TADA2A Fusion FISH Probe is used to confirm a fusion of the ACACA and TADA2A genes. The fusion of the ACACA and TADA2A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACACA-TADA2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-RERE | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-REOR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-REGO | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-REGR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-REAQ | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-ORRE | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-OROR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-ORGO | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GORE | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GOOR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GOGO | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GOGR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GRRE | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GROR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GRGO | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GRGR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-AQRE | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-AQOR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-AQGO | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-AQGR | 20 (40 μL) | 200 μL |
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| ACACA-TADA2A-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACA Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Alpha
Chromosome: CHR17: 35441926 -35766902
Locus: 17q12
TADA2A Gene Summary
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Gene Name: Transcriptional Adaptor 2A
Chromosome: CHR17: 35766976 -35837226
Locus: 17q12
Gene Diseases
The ACACA TADA2A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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