ACACA-LASP1 Fusion FISH Probe
The ACACA-LASP1 Fusion FISH Probe is used to confirm a fusion of the ACACA and LASP1 genes. The fusion of the ACACA and LASP1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACACA-LASP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-RERE | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-REOR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-REGO | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-REGR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-OROR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GORE | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GROR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACACA-LASP1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACA Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Alpha
Chromosome: CHR17: 35441926 -35766902
Locus: 17q12
LASP1 Gene Summary
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Gene Name: LIM And SH3 Protein 1
Chromosome: CHR17: 37026111 -37078023
Locus: 17q12
Gene Diseases
The ACACA LASP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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