ABR-YWHAE Fusion FISH Probe
The ABR-YWHAE Fusion FISH Probe is used to confirm a fusion of the ABR and YWHAE genes. The fusion of the ABR and YWHAE genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABR-YWHAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-RERE | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-REOR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-REGO | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-REGR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-REAQ | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-ORRE | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-OROR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-ORGO | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GORE | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GOOR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GOGO | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GOGR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GRRE | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GROR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GRGO | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GRGR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-AQRE | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-AQOR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-AQGO | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-AQGR | 20 (40 μL) | 200 μL |
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| ABR-YWHAE-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
YWHAE Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Chromosome: CHR17: 1247833 -1303556
Locus: 17p13.3
Gene Diseases
The ABR YWHAE Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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