ABR-MAN2B1 Fusion FISH Probe
The ABR-MAN2B1 Fusion FISH Probe is used to confirm a fusion of the ABR and MAN2B1 genes. The fusion of the ABR and MAN2B1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABR-MAN2B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-RERE | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-REOR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-REGO | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-REGR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-REAQ | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-ORRE | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-OROR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-ORGO | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GORE | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GOOR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GOGO | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GOGR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GRRE | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GROR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GRGO | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GRGR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-AQRE | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-AQOR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-AQGO | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-AQGR | 20 (40 μL) | 200 μL |
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| ABR-MAN2B1-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
MAN2B1 Gene Summary
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Gene Name: Mannosidase Alpha Class 2B Member 1
Chromosome: CHR19: 12757321 -12777591
Locus: 19p13.13
Gene Diseases
The ABR MAN2B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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