ABL1-PTPRN2 Fusion FISH Probe
The ABL1-PTPRN2 Fusion FISH Probe is used to confirm a fusion of the ABL1 and PTPRN2 genes. The fusion of the ABL1 and PTPRN2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABL1-PTPRN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-RERE | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-REOR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-REGO | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-REGR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-REAQ | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-ORRE | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-OROR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-ORGO | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GORE | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GOOR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GOGO | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GOGR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GRRE | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GROR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GRGO | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GRGR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-AQRE | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-AQOR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-AQGO | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-AQGR | 20 (40 μL) | 200 μL |
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| ABL1-PTPRN2-20-AQAQ | 20 (40 μL) | 200 μL |
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ABL1 Gene Summary
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267 -133763062
Locus: 9q34.12
PTPRN2 Gene Summary
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type N2
Chromosome: CHR7: 157331749 -158380482
Locus: 7q36.3
Gene Diseases
The ABL1 PTPRN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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