ABL1-DDX27 Fusion FISH Probe
The ABL1-DDX27 Fusion FISH Probe is used to confirm a fusion of the ABL1 and DDX27 genes. The fusion of the ABL1 and DDX27 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABL1-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| ABL1-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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ABL1 Gene Summary
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267 -133763062
Locus: 9q34.12
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The ABL1 DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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