ABL1-DDX27 Fusion FISH Probe

The ABL1-DDX27 Fusion FISH Probe is used to confirm a fusion of the ABL1 and DDX27 genes. The fusion of the ABL1 and DDX27 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads. Typical turnaround time for this product is 7-14 days after purchase.

ABL1-DDX27 Fusion FISH Probe

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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SKU Test Kits Buffer Dye Color Order Now
ABL1-DDX27-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ABL1-DDX27-20-RERE 20 (40 μL) 200 μL
ABL1-DDX27-20-REOR 20 (40 μL) 200 μL
ABL1-DDX27-20-REGO 20 (40 μL) 200 μL
ABL1-DDX27-20-REGR 20 (40 μL) 200 μL
ABL1-DDX27-20-REAQ 20 (40 μL) 200 μL
ABL1-DDX27-20-ORRE 20 (40 μL) 200 μL
ABL1-DDX27-20-OROR 20 (40 μL) 200 μL
ABL1-DDX27-20-ORGO 20 (40 μL) 200 μL
ABL1-DDX27-20-ORAQ 20 (40 μL) 200 μL
ABL1-DDX27-20-GORE 20 (40 μL) 200 μL
ABL1-DDX27-20-GOOR 20 (40 μL) 200 μL
ABL1-DDX27-20-GOGO 20 (40 μL) 200 μL
ABL1-DDX27-20-GOGR 20 (40 μL) 200 μL
ABL1-DDX27-20-GOAQ 20 (40 μL) 200 μL
ABL1-DDX27-20-GRRE 20 (40 μL) 200 μL
ABL1-DDX27-20-GROR 20 (40 μL) 200 μL
ABL1-DDX27-20-GRGO 20 (40 μL) 200 μL
ABL1-DDX27-20-GRGR 20 (40 μL) 200 μL
ABL1-DDX27-20-GRAQ 20 (40 μL) 200 μL
ABL1-DDX27-20-AQRE 20 (40 μL) 200 μL
ABL1-DDX27-20-AQOR 20 (40 μL) 200 μL
ABL1-DDX27-20-AQGO 20 (40 μL) 200 μL
ABL1-DDX27-20-AQGR 20 (40 μL) 200 μL
ABL1-DDX27-20-AQAQ 20 (40 μL) 200 μL

ABL1 Gene Summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase

Chromosome: CHR9: 133589267 -133763062

Locus: 9q34.12

DDX27 Gene Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

Gene Name: DEAD-box Helicase 27

Chromosome: CHR20: 47835831 -47860614

Locus: 20q13.13

Gene Diseases

The ABL1 DDX27 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.