ABL1-ADAMTSL2 Fusion FISH Probe
The ABL1-ADAMTSL2 Fusion FISH Probe is used to confirm a fusion of the ABL1 and ADAMTSL2 genes. The fusion of the ABL1 and ADAMTSL2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABL1-ADAMTSL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-RERE | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-REOR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-REGO | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-REGR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-REAQ | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-ORRE | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-OROR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-ORGO | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GORE | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GOOR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GOGO | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GOGR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GRRE | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GROR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GRGO | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GRGR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-AQRE | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-AQOR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-AQGO | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-AQGR | 20 (40 μL) | 200 μL |
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| ABL1-ADAMTSL2-20-AQAQ | 20 (40 μL) | 200 μL |
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ABL1 Gene Summary
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267 -133763062
Locus: 9q34.12
ADAMTSL2 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]
Gene Name: ADAMTS Like 2
Chromosome: CHR9: 136397285 -136440641
Locus: 9q34.2
Gene Diseases
The ABL1 ADAMTSL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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