ABI1-PTP4A3 Fusion FISH Probe
The ABI1-PTP4A3 Fusion FISH Probe is used to confirm a fusion of the ABI1 and PTP4A3 genes. The fusion of the ABI1 and PTP4A3 genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABI1-PTP4A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-RERE | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-REOR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-REGO | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-REGR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-REAQ | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-ORRE | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-OROR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-ORGO | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GORE | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GOOR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GOGO | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GOGR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GRRE | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GROR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GRGO | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GRGR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-AQRE | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-AQOR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-AQGO | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-AQGR | 20 (40 μL) | 200 μL |
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| ABI1-PTP4A3-20-AQAQ | 20 (40 μL) | 200 μL |
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ABI1 Gene Summary
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
Gene Name: Abl Interactor 1
Chromosome: CHR10: 27035524 -27150016
Locus: 10p12.1
PTP4A3 Gene Summary
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Protein Tyrosine Phosphatase Type IVA, Member 3
Chromosome: CHR8: 142432006 -142441620
Locus: 8q24.3
Gene Diseases
The ABI1 PTP4A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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