ABI1-CUBN Fusion FISH Probe
The ABI1-CUBN Fusion FISH Probe is used to confirm a fusion of the ABI1 and CUBN genes. The fusion of the ABI1 and CUBN genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABI1-CUBN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-RERE | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-REOR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-REGO | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-REGR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-REAQ | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-ORRE | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-OROR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-ORGO | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GORE | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GOOR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GOGO | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GOGR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GRRE | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GROR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GRGO | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GRGR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-AQRE | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-AQOR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-AQGO | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-AQGR | 20 (40 μL) | 200 μL |
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| ABI1-CUBN-20-AQAQ | 20 (40 μL) | 200 μL |
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CUBN Gene Summary
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]
Gene Name: Cubilin
Chromosome: CHR10: 16865964 -17171816
Locus: 10p13
ABI1 Gene Summary
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
Gene Name: Abl Interactor 1
Chromosome: CHR10: 27035524 -27150016
Locus: 10p12.1
Gene Diseases
The ABI1 CUBN Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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