ABCC4-PTPN4 Fusion FISH Probe
The ABCC4-PTPN4 Fusion FISH Probe is used to confirm a fusion of the ABCC4 and PTPN4 genes. The fusion of the ABCC4 and PTPN4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCC4-PTPN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-RERE | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-REOR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-REGO | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-REGR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-OROR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GORE | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GROR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCC4-PTPN4-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN4 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 4
Chromosome: CHR2: 120517206 -120735037
Locus: 2q14.2
ABCC4 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Name: ATP Binding Cassette Subfamily C Member 4
Chromosome: CHR13: 95672082 -95953687
Locus: 13q32.1
Gene Diseases
The ABCC4 PTPN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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