ABCC2-CTNNA3 Fusion FISH Probe
The ABCC2-CTNNA3 Fusion FISH Probe is used to confirm a fusion of the ABCC2 and CTNNA3 genes. The fusion of the ABCC2 and CTNNA3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCC2-CTNNA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-RERE | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-REOR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-REGO | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-REGR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-OROR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GORE | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GROR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCC2-CTNNA3-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC2 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily C Member 2
Chromosome: CHR10: 101542462 -101611662
Locus: 10q24.2
CTNNA3 Gene Summary
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Catenin Alpha 3
Chromosome: CHR10: 67679724 -69455949
Locus: 10q21.3
Gene Diseases
The ABCC2 CTNNA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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