ABCC1-NDE1 Fusion FISH Probe
The ABCC1-NDE1 Fusion FISH Probe is used to confirm a fusion of the ABCC1 and NDE1 genes. The fusion of the ABCC1 and NDE1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCC1-NDE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-RERE | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-REOR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-REGO | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-REGR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-OROR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GORE | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GROR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCC1-NDE1-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC1 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Gene Name: ATP Binding Cassette Subfamily C Member 1
Chromosome: CHR16: 16043433 -16236930
Locus: 16p13.11
NDE1 Gene Summary
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Name: NudE Neurodevelopment Protein 1
Chromosome: CHR16: 15737123 -15820208
Locus: 16p13.11
Gene Diseases
The ABCC1 NDE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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