ABCB8-NOS3 Fusion FISH Probe
The ABCB8-NOS3 Fusion FISH Probe is used to confirm a fusion of the ABCB8 and NOS3 genes. The fusion of the ABCB8 and NOS3 genes has been associated with Breast Invasive Carcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCB8-NOS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-RERE | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-REOR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-REGO | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-REGR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-OROR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GORE | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GROR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCB8-NOS3-20-AQAQ | 20 (40 μL) | 200 μL |
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NOS3 Gene Summary
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Nitric Oxide Synthase 3
Chromosome: CHR7: 150688143 -150711687
Locus: 7q36.1
ABCB8 Gene Summary
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: ATP Binding Cassette Subfamily B Member 8
Chromosome: CHR7: 150725509 -150744869
Locus: 7q36.1
Gene Diseases
The ABCB8 NOS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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