ABCA7-COL5A3 Fusion FISH Probe
The ABCA7-COL5A3 Fusion FISH Probe is used to confirm a fusion of the ABCA7 and COL5A3 genes. The fusion of the ABCA7 and COL5A3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCA7-COL5A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-RERE | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-REOR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-REGO | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-REGR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-OROR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GORE | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GROR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCA7-COL5A3-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCA7 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily A Member 7
Chromosome: CHR19: 1040101 -1065570
Locus: 19p13.3
COL5A3 Gene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]
Gene Name: Collagen Type V Alpha 3 Chain
Chromosome: CHR19: 10070236 -10121147
Locus: 19p13.2
Gene Diseases
The ABCA7 COL5A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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