AATF-LIG3 Fusion FISH Probe
The AATF-LIG3 Fusion FISH Probe is used to confirm a fusion of the AATF and LIG3 genes. The fusion of the AATF and LIG3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AATF-LIG3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-RERE | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-REOR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-REGO | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-REGR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-REAQ | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-ORRE | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-OROR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-ORGO | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GORE | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GOOR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GOGO | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GOGR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GRRE | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GROR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GRGO | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GRGR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-AQRE | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-AQOR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-AQGO | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-AQGR | 20 (40 μL) | 200 μL |
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| AATF-LIG3-20-AQAQ | 20 (40 μL) | 200 μL |
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LIG3 Gene Summary
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: DNA Ligase 3
Chromosome: CHR17: 33307516 -33332088
Locus: 17q12
AATF Gene Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Gene Name: Apoptosis Antagonizing Transcription Factor
Chromosome: CHR17: 35306174 -35414171
Locus: 17q12
Gene Diseases
The AATF LIG3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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