AATF-FTL Fusion FISH Probe
The AATF-FTL Fusion FISH Probe is used to confirm a fusion of the AATF and FTL genes. The fusion of the AATF and FTL genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AATF-FTL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-RERE | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-REOR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-REGO | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-REGR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-REAQ | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-ORRE | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-OROR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-ORGO | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-ORAQ | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GORE | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GOOR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GOGO | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GOGR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GOAQ | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GRRE | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GROR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GRGO | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GRGR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-GRAQ | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-AQRE | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-AQOR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-AQGO | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-AQGR | 20 (40 μL) | 200 μL |
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| AATF-FTL-20-AQAQ | 20 (40 μL) | 200 μL |
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FTL Gene Summary
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Gene Name: Ferritin Light Chain
Chromosome: CHR19: 49468565 -49470136
Locus: 19q13.33
AATF Gene Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Gene Name: Apoptosis Antagonizing Transcription Factor
Chromosome: CHR17: 35306174 -35414171
Locus: 17q12
Gene Diseases
The AATF FTL Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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