AARS-PPP1R13B Fusion FISH Probe
The AARS-PPP1R13B Fusion FISH Probe is used to confirm a fusion of the AARS and PPP1R13B genes. The fusion of the AARS and PPP1R13B genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AARS-PPP1R13B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-RERE | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-REOR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-REGO | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-REGR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-REAQ | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-ORRE | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-OROR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-ORGO | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-ORAQ | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GORE | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GOOR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GOGO | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GOGR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GOAQ | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GRRE | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GROR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GRGO | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GRGR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-GRAQ | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-AQRE | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-AQOR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-AQGO | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-AQGR | 20 (40 μL) | 200 μL |
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| AARS-PPP1R13B-20-AQAQ | 20 (40 μL) | 200 μL |
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AARS Gene Summary
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
Gene Name: Alanyl-tRNA Synthetase
Chromosome: CHR16: 70286296 -70323412
Locus: 16q22.1
PPP1R13B Gene Summary
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 13B
Chromosome: CHR14: 104200087 -104313927
Locus: 14q32.33
Gene Diseases
The AARS PPP1R13B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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