AAK1-WFDC13 Fusion FISH Probe
The AAK1-WFDC13 Fusion FISH Probe is used to confirm a fusion of the AAK1 and WFDC13 genes. The fusion of the AAK1 and WFDC13 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AAK1-WFDC13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-RERE | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-REOR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-REGO | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-REGR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-REAQ | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-ORRE | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-OROR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-ORGO | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-ORAQ | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GORE | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GOOR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GOGO | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GOGR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GOAQ | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GRRE | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GROR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GRGO | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GRGR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-GRAQ | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-AQRE | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-AQOR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-AQGO | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-AQGR | 20 (40 μL) | 200 μL |
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| AAK1-WFDC13-20-AQAQ | 20 (40 μL) | 200 μL |
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AAK1 Gene Summary
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: AP2 Associated Kinase 1
Chromosome: CHR2: 69685126 -69870977
Locus: 2p13.3
WFDC13 Gene Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]
Gene Name: WAP Four-disulfide Core Domain 13
Chromosome: CHR20: 44330654 -44337456
Locus: 20q13.12
Gene Diseases
The AAK1 WFDC13 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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