AAK1-RPIA Fusion FISH Probe
The AAK1-RPIA Fusion FISH Probe is used to confirm a fusion of the AAK1 and RPIA genes. The fusion of the AAK1 and RPIA genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AAK1-RPIA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-RERE | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-REOR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-REGO | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-REGR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-REAQ | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-ORRE | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-OROR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-ORGO | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-ORAQ | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GORE | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GOOR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GOGO | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GOGR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GOAQ | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GRRE | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GROR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GRGO | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GRGR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-GRAQ | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-AQRE | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-AQOR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-AQGO | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-AQGR | 20 (40 μL) | 200 μL |
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| AAK1-RPIA-20-AQAQ | 20 (40 μL) | 200 μL |
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AAK1 Gene Summary
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: AP2 Associated Kinase 1
Chromosome: CHR2: 69685126 -69870977
Locus: 2p13.3
RPIA Gene Summary
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Gene Name: Ribose 5-phosphate Isomerase A
Chromosome: CHR2: 88991175 -89050452
Locus: 2p11.2
Gene Diseases
The AAK1 RPIA Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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