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AAGAB-SMAD3 Fusion FISH Probe

The AAGAB-SMAD3 Fusion FISH Probe is used to confirm a fusion of the AAGAB and SMAD3 genes. The fusion of the AAGAB and SMAD3 genes has been associated with Sarcoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
AAGAB-SMAD3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
AAGAB-SMAD3-20-RERE 20 (40 μL) 200 μL
AAGAB-SMAD3-20-REOR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-REGO 20 (40 μL) 200 μL
AAGAB-SMAD3-20-REGR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-REAQ 20 (40 μL) 200 μL
AAGAB-SMAD3-20-ORRE 20 (40 μL) 200 μL
AAGAB-SMAD3-20-OROR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-ORGO 20 (40 μL) 200 μL
AAGAB-SMAD3-20-ORAQ 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GORE 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GOOR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GOGO 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GOGR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GOAQ 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GRRE 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GROR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GRGO 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GRGR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-GRAQ 20 (40 μL) 200 μL
AAGAB-SMAD3-20-AQRE 20 (40 μL) 200 μL
AAGAB-SMAD3-20-AQOR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-AQGO 20 (40 μL) 200 μL
AAGAB-SMAD3-20-AQGR 20 (40 μL) 200 μL
AAGAB-SMAD3-20-AQAQ 20 (40 μL) 200 μL

SMAD3 Gene Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

Gene Name: SMAD Family Member 3

Chromosome: CHR15: 67358194 -67487533

Locus: 15q22.33

AAGAB Gene Summary

The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Name: Alpha And Gamma Adaptin Binding Protein

Chromosome: CHR15: 67493366 -67547074

Locus: 15q23

Gene Diseases

The AAGAB SMAD3 Fusion has been associated with the following diseases:

Disease Name
Sarcoma
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.