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A2M-FAR1 Fusion FISH Probe

The A2M-FAR1 Fusion FISH Probe is used to confirm a fusion of the A2M and FAR1 genes. The fusion of the A2M and FAR1 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads. Typical turnaround time for this product is 7-14 days after purchase.

A2M-FAR1 Fusion FISH Probe

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

Download FISH ProtocolDownload Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
A2M-FAR1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
A2M-FAR1-20-RERE 20 (40 μL) 200 μL
A2M-FAR1-20-REOR 20 (40 μL) 200 μL
A2M-FAR1-20-REGO 20 (40 μL) 200 μL
A2M-FAR1-20-REGR 20 (40 μL) 200 μL
A2M-FAR1-20-REAQ 20 (40 μL) 200 μL
A2M-FAR1-20-ORRE 20 (40 μL) 200 μL
A2M-FAR1-20-OROR 20 (40 μL) 200 μL
A2M-FAR1-20-ORGO 20 (40 μL) 200 μL
A2M-FAR1-20-ORAQ 20 (40 μL) 200 μL
A2M-FAR1-20-GORE 20 (40 μL) 200 μL
A2M-FAR1-20-GOOR 20 (40 μL) 200 μL
A2M-FAR1-20-GOGO 20 (40 μL) 200 μL
A2M-FAR1-20-GOGR 20 (40 μL) 200 μL
A2M-FAR1-20-GOAQ 20 (40 μL) 200 μL
A2M-FAR1-20-GRRE 20 (40 μL) 200 μL
A2M-FAR1-20-GROR 20 (40 μL) 200 μL
A2M-FAR1-20-GRGO 20 (40 μL) 200 μL
A2M-FAR1-20-GRGR 20 (40 μL) 200 μL
A2M-FAR1-20-GRAQ 20 (40 μL) 200 μL
A2M-FAR1-20-AQRE 20 (40 μL) 200 μL
A2M-FAR1-20-AQOR 20 (40 μL) 200 μL
A2M-FAR1-20-AQGO 20 (40 μL) 200 μL
A2M-FAR1-20-AQGR 20 (40 μL) 200 μL
A2M-FAR1-20-AQAQ 20 (40 μL) 200 μL

A2M Gene Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Gene Name: Alpha-2-macroglobulin

Chromosome: CHR12: 9220303 -9268558

Locus: 12p13.31

FAR1 Gene Summary

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]

Gene Name: Fatty Acyl-CoA Reductase 1

Chromosome: CHR11: 13690205 -13753893

Locus: 11p15.3

Gene Diseases

The A2M FAR1 Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.