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A2M-CCT5 Fusion FISH Probe

The A2M-CCT5 Fusion FISH Probe is used to confirm a fusion of the A2M and CCT5 genes. The fusion of the A2M and CCT5 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
A2M-CCT5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
A2M-CCT5-20-RERE 20 (40 μL) 200 μL
A2M-CCT5-20-REOR 20 (40 μL) 200 μL
A2M-CCT5-20-REGO 20 (40 μL) 200 μL
A2M-CCT5-20-REGR 20 (40 μL) 200 μL
A2M-CCT5-20-REAQ 20 (40 μL) 200 μL
A2M-CCT5-20-ORRE 20 (40 μL) 200 μL
A2M-CCT5-20-OROR 20 (40 μL) 200 μL
A2M-CCT5-20-ORGO 20 (40 μL) 200 μL
A2M-CCT5-20-ORAQ 20 (40 μL) 200 μL
A2M-CCT5-20-GORE 20 (40 μL) 200 μL
A2M-CCT5-20-GOOR 20 (40 μL) 200 μL
A2M-CCT5-20-GOGO 20 (40 μL) 200 μL
A2M-CCT5-20-GOGR 20 (40 μL) 200 μL
A2M-CCT5-20-GOAQ 20 (40 μL) 200 μL
A2M-CCT5-20-GRRE 20 (40 μL) 200 μL
A2M-CCT5-20-GROR 20 (40 μL) 200 μL
A2M-CCT5-20-GRGO 20 (40 μL) 200 μL
A2M-CCT5-20-GRGR 20 (40 μL) 200 μL
A2M-CCT5-20-GRAQ 20 (40 μL) 200 μL
A2M-CCT5-20-AQRE 20 (40 μL) 200 μL
A2M-CCT5-20-AQOR 20 (40 μL) 200 μL
A2M-CCT5-20-AQGO 20 (40 μL) 200 μL
A2M-CCT5-20-AQGR 20 (40 μL) 200 μL
A2M-CCT5-20-AQAQ 20 (40 μL) 200 μL

A2M Gene Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Gene Name: Alpha-2-macroglobulin

Chromosome: CHR12: 9220303 -9268558

Locus: 12p13.31

CCT5 Gene Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

Gene Name: Chaperonin Containing TCP1 Subunit 5

Chromosome: CHR5: 10250281 -10266501

Locus: 5p15.2

Gene Diseases

The A2M CCT5 Fusion has been associated with the following diseases:

Disease Name
Liver Hepatocellular Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.