A2M-CCT5 Fusion FISH Probe
The A2M-CCT5 Fusion FISH Probe is used to confirm a fusion of the A2M and CCT5 genes. The fusion of the A2M and CCT5 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| A2M-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| A2M-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
|
A2M Gene Summary
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Name: Alpha-2-macroglobulin
Chromosome: CHR12: 9220303 -9268558
Locus: 12p13.31
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The A2M CCT5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|