A2M-ARFGEF2 Fusion FISH Probe
The A2M-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the A2M and ARFGEF2 genes. The fusion of the A2M and ARFGEF2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| A2M-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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A2M Gene Summary
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Name: Alpha-2-macroglobulin
Chromosome: CHR12: 9220303 -9268558
Locus: 12p13.31
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The A2M ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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