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Acute Promyelocytic Leukemia FISH Probes


Acute promyelocytic leukemia is genetically characterized by the balanced translocation t(15;17) (q24;q21), which fuses the retinoic acid receptor alpha (RARA) gene and the promyelocytic leukemia (PML) gene. The fusion both represses myeloid differentiation, and promotes survival and proliferation of leukemic cells.