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NISH HPV High Risk Probe
NISH
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NISH HPV High Risk Probe

$950.00

SKU: HPV-HR Categories: , , , , , , Brand:

Kit Components

Probe A

Probe B

The NISH HPV High Risk Probe is a dual-probe in situ hybridization (ISH) assay designed for the qualitative detection of E6/E7 mRNA transcripts from 18 high-risk human papillomavirus (HPV) genotypes — including types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82 — in formalin-fixed, paraffin-embedded (FFPE) tissue sections. By targeting E6/E7 mRNA rather than HPV DNA, this assay enables detection of active viral transcription at the cellular level, providing researchers with functional insight into HPV expression within preserved tissue morphology. The broad genotype coverage of the dual-probe format (HPV HR A & B) supports wide-spectrum high-risk HPV research in a single assay. Powered by HCR™ Pro, the NISH HPV High Risk Probe generates high-sensitivity chromogenic signal with low background. The probe is supplied ready-to-use and integrates with the NISH HRP and AP Detection Kit and NISH DAB or Red Kit on the NeoPath Pro Automated Stainer. For Research Use Only. Not for use in diagnostic procedures.

Product Specifications

Catalog Number
HPV-HR-20-R-NP
Pack Size
20 Tests
Target
E6/E7 mRNA from High-Risk HPV Genotypes (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82)
Probe Format
Dual-probe set (HPV HR A & B)
Detection Analyte
E6/E7 mRNA
Species Reactivity
Human
Sample Type
FFPE tissue sections
Application
In situ hybridization (ISH)
Protocol Name
HPV High Risk ISH
Storage
4°C, protected from light
Regulatory Status
For Research Use Only (RUO)
Technology
HCR™ Pro

Frequently Asked Questions (FAQ)

?What genotypes NISH HPV High Risk Probe cover?

The probe covers 18 high-risk genotypes: HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82.

?Does the NISH HPV High Risk Probe detect RNA or DNA?

The probe targets E6/E7 mRNA transcripts, enabling detection of active HPV gene expression in FFPE tissue sections.

?What detection system is used with the NISH HPV High Risk Probe?

The probe is designed for use with the NISH HRP Detection Kit and NISH DAB Kit as well as the NISH AP Detection Kit and NISH Red Kit, producing a brown or red chromogenic signal visible under brightfield microscopy.

?What instrument is required?

The NISH HPV High Risk Probe is intended for use with the NeoPath Pro Automated Stainer (NPP0001).

?How does this probe differ form the NISH HPV 16/18 Probe?

The NISH HPV High Risk Probe targets E6/E7 mRNA across 18 high-risk genotypes, while the NISH HPV 16/18 Probe detects HPV 16 and 18 RNA specifically.

Certificate of Analysis (CoA)

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Documentation

PDF icon NISH HPV High Risk Probe Datasheet
PDF icon NISH Probe SDS
PDF icon NISH Probe Hybridization Buffer SDS

Customer Publications

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