Signal to Noise is Empire Genomics’ dedicated education center—bringing together foundational knowledge, expert insights, and real-world FISH applications in one place. From the history and scientific principles behind fluorescence in situ hybridization to practical guidance from our Field Application Scientists, this is where complexity becomes clarity.
Whether you’re exploring the fundamentals of probe design, understanding workflow considerations, or reviewing practical insights from the bench, Signal to Noise is built to support laboratories at every stage of experience. Our goal is simple: deliver meaningful, science-driven education that strengthens performance, improves consistency, and builds confidence in every result.
All signal. No noise.
Teagan’s Tech Tip: Avoiding Hybridization Artifacts Straight from the bench, our Field Application Scientist Teagan shares a few simple—but impactful—ways to reduce hybridization artifacts and improve signal-to-noise in your FISH workflow: Start with properly conditioned reagents Let your...
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Are Your Fluorophores Working for You—or Against You? In fluorescence in situ hybridization (FISH), performance is often judged by probe design, but in reality, fluorophore behavior is just as critical to signal quality. Even a well-designed probe can...
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Fluorescence in situ hybridization (FISH) didn’t just change how we see the genome; it redefined the speed of clinical discovery. To understand where the technology is going, we have to look at the hurdles it has cleared over the last...
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If you’ve ever applied a FISH probe and watched it bead up instead of spreading evenly, you’re not alone—and it’s one of the most common issues labs encounter during hybridization. In this edition of Teagan’s Tech Tip, we...
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