The NTRK gene family is made up of NTRK1, NTRK2, and NTRK3, which encode proteins TRKA, TRKB, and TRKC, respectively. NTRK genes promote cancer via fusions with other genes that constitutively activate the receptors. So far, over 80 different NTRK fusion partners have been identified, and more continue to be discovered.

The first NTRK1 fusion was identified in the 1980s in colon cancer. The gene was the first of the NTRK family to be characterized as a tumor driver. Fusion partners include LMNA, TPM3, and IRF2BP2.

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NTRK2 fusions were first detected in pilocytic astrocytoma, and shortly afterwards in pontine glioma. Fusion partners include NOS1AP, DAP21P, and TRAF2.

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NTRK3’s first documented fusion was to ETV6 in infantile fibrosarcoma. The fusion has since been found to drive several other malignancies. Additional fusion partners include EML4 and RBPMS.

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