NISH Positive Control Probe
$200.00
Kit Components
Probe A
Probe B
The NISH Positive Control Probe is an in situ hybridization (ISH) reagent designed to confirm assay sensitivity and verify nucleic acid integrity in FFPE tissue sections. It targets PPIB (Peptidylprolyl Isomerase B, also known as Cyclophilin B) — a constitutively expressed housekeeping gene and widely adopted industry-standard positive control sequence in ISH workflows.
Because PPIB is ubiquitously expressed across human tissue types, a robust signal with this probe confirms that the tissue sample has preserved nucleic acid of sufficient quality and that the ISH assay has been performed correctly. Absence of signal may indicate tissue degradation, processing issues, or protocol failure rather than true target negativity.
Powered by HCR™ Pro, this probe delivers sensitive, high-clarity signal with minimal background. It is supplied ready-to-use in hybridization buffer and is compatible with the NISH HRP and AP Detection Kit and NISH DAB or Red Kit on the NeoPath Pro Automated Stainer. For Research Use Only. Not for use in diagnostic procedures.Product Specifications
Frequently Asked Questions (FAQ)
?What is the target of the NISH Positive Control Probe?
The probe targets PPIB (Peptidylprolyl Isomerase B / Cyclophilin B), a constitutively expressed housekeeping gene used as an industry-standard positive control in ISH assays to confirm tissue RNA integrity and assay performance.
?What instrument is required?
The probe is intended for use with the NeoPath Pro Automated Stainer (NPP0001).
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