KAT6A-CREBBP Fusion FISH probe
Our KAT6A/CREBBP fusion probe is designed to detect fusions between KAT6A and CREBBP. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: KAT6A codes for a zinc finger protein that regulates transcription via activation of RUNX1, while CREBBP encodes a ubiquitously expressed protein that monitors central cell cycle functions. The t(8;16)(p11;p13) rearrangement generates the KAT6A/CREBBP fusion, a rare but recurrent abnormality found in approximately 0.2-0.4% of acute myeloid leukemia (AML) patients. As of 2019, only about 100 cases of KAT6A/CREBBP-positive AML had been reported, mostly as single case reports. The abnormality is more common in therapy-related and neonatal AML.
Source: Xie W, t al. (2019) Annals of hematology 98.5: 1149-1157.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|KAT6A-CREBBP-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
|KAT6A-CREBBP-20-GOGR||20 (40 μL)||200 μL|
|KAT6A-CREBBP-20-REGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|