KAT6A-CREBBP Fusion FISH probe

Our KAT6A/CREBBP fusion probe is designed to detect fusions between KAT6A and CREBBP. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: KAT6A codes for a zinc finger protein that regulates transcription via activation of RUNX1, while CREBBP encodes a ubiquitously expressed protein that monitors central cell cycle functions. The t(8;16)(p11;p13) rearrangement generates the KAT6A/CREBBP fusion, a rare but recurrent abnormality found in approximately 0.2-0.4% of acute myeloid leukemia (AML) patients. As of 2019, only about 100 cases of KAT6A/CREBBP-positive AML had been reported, mostly as single case reports. The abnormality is more common in therapy-related and neonatal AML.

Source: Xie W, t al. (2019) Annals of hematology 98.5: 1149-1157.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KAT6A-CREBBP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
KAT6A-CREBBP-20-GOGR 20 (40 μL) 200 μL
KAT6A-CREBBP-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Gene Details

Gene Symbol: KAT6A

Gene Name: Lysine Acetyltransferase 6A

Chromosome: CHR8: 41786996-41909505

Locus: 8p11.21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.