GLIS2/CBFA2T3 Fusion FISH Probe
Our GLIS2/CBFA2T3 fusion probe is designed to detect fusions between GLIS2 and CBFA2T3. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: CBFA2T3-GLIS2 is a fusion gene found in 17% of non-Down syndrome acute megakaryoblastic leukemia (non-DS AMKL) and 8% of pediatric cytogenetically normal acute myeloid leukemia (CN-AML) cases. CBFA2T3 was initially identified as a fusion partner with RUNX1 in rare cases of therapy-related AML. The gene encodes a transcriptional repressor that helps regulate hematopoietic stem cell quiescence. GLIS2 is a member of the GLI-similar (GLIS1-3) subfamily of Krüppel-like zinc finger transcription factors. Its fusion to CBFA2T3 as a result of the inv(16)(p13.3q24.3) leads to upregulation of both Hedgehog and bone morphogenic protein (BMP) signaling.
Source: Gruber T, et al. (2012) Cancer Cell 22.5:683-697.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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GLIS2-CBFA2T3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL | ||
GLIS2-CBFA2T3-20-GOGR | 20 (40 μL) | 200 μL | ||
GLIS2-CBFA2T3-20-REGR | 20 (40 μL) | 200 μL |
Gene Summary
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
Gene Details
Gene Symbol: GLIS2
Gene Name: GLIS Family Zinc Finger 2
Chromosome: CHR16: 4382224-4389598
Locus: 16p13.3
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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