PBX1/TCF3 Fusion FISH Probe

Our PBX1/TCF3 fusion probe is designed to detect fusions between PBX1 and TCF3. The probe comes labeled in orange and green, but can be customized to meet your needs.

Gene Background: PBX1-TCF3 fusion is one of the most prevalent rearrangements in B-ALL, occurring in about 6% of adult and childhood patients. The fusion is generated by either the balanced t(1;19)(q23;p13) or the unbalanced der(19)t(1;19)(q23;p13) translocation. Its encoded protein is a transcription factor bearing the transactivation domain of TCF3 and the DNA-binding domain of PBX1, resulting in constitutive activation of PBX1-bound proteins.

Source: Tirado C, et al. (2015) Biomarker research. 3.1: 4.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PBX1-TCF3-20-ORGR 20 (40 μL) 200 μL
PBX1-TCF3-20-GOGR 20 (40 μL) 200 μL
PBX1-TCF3-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Gene Details

Gene Symbol: PBX1

Gene Name: PBX Homeobox 1

Chromosome: CHR1: 164528596-164821060

Locus: 1q23.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.