MYH11/CBFB Extended Fusion FISH Probe
Our MYH11/CBFB fusion probe is designed to detect fusions between MYH11 and CBFB. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: Acute myeloid leukemia (AML) with inv(16)(p13q22) accounts for about 5–7% of all de novo AML cases. The rearrangement results in fusion of the core-binding factor subunit beta (CBFB) gene and the myosin heavy chain 11 (MYH11) gene. At least 12 different MYH11-CBFB fusion transcripts have been reported, arising from multiple breakpoints in MYH11. The majority (85%) of such cases have type A fusion transcripts, followed by type D and E (5% each). Descriptions of the rare fusion types B, C, and F–K, and two additional types, are mostly based on single case reports. The resulting MYH11-CBFB chimeric protein interrupts the formation of the CBF complex and blocks the differentiation of hematopoietic cells.
Source: Kurata K, et al. 2019. Cancer Genetics
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH11-CBFB-ext-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH11-CBFB-ext-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH11-CBFB-ext-20-GRGO | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MYH11
Gene Name: Myosin Heavy Chain 11
Chromosome: CHR16: 15796991-15950887
Locus: 16p13.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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