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RUNX1T1-RUNX1 Fusion FISH Probe

Our RUNX1T1/RUNX1 fusion probe is designed to detect fusions between RUNX1T1 and RUNX1. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: Acute myeloid leukemia (AML) harboring RUNX1-RUNX1T1 fusion is now a WHO-recognized AML subset.1 The fusion is found in approximately 5-12% of AML patients, and is more common in children and young adults.2 The t(8;21) breakpoint usually occurs in the intron between exons 5 and 6, just before the transactivation domain.2 The generated fusion protein is made up of the DNA-binding domain of RUNX1 fused to the transcription factor RUNX1T1, and is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.3

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
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SKU Test Kits Buffer Dye Color Order Now
RUNX1T1-RUNX1-20-GROR  (Standard Design) 20 (40 μL) 200 μL
RUNX1T1-RUNX1-20-ORGR 20 (40 μL) 200 μL
RUNX1T1-RUNX1-20-GRRE 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Gene Details

Gene Symbol: RUNX1T1

Gene Name: RUNX1 Translocation Partner 1

Chromosome: CHR8: 92967194-93115454

Locus: 8q21.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.