DUX4/CIC Fusion FISH Probe
Our DUX4/CIC fusion probe is designed to detect fusions between DUX4 and CIC. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: CIC encodes a high-mobility group box transcription factor, while DUX4 codes for a double homeobox transcription factor.1 Fusion of the genes results in a CIC-dominant chimera that up-regulates the PEA3 subfamily of ETS, including ETV1, ETV4, and ETV5.1 The fusion is a hallmark of undifferentiated small round cell sarcomas, affecting primarily children and young adults.2 CIC-DUX4 sarcomas are morphologically similar to Ewing sarcomas, but lack the EWSRT or TET family rearrangements specific to ES.3
*The region in which DUX4 lies is known for high levels of cross-homology with other genomic regions, which can lead to diffuse probe signals.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|DUX4-CIC-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
|DUX4-CIC-20-GOGR||20 (40 μL)||200 μL|
|DUX4-CIC-20-AQGR||20 (40 μL)||200 μL|
|DUX4-CIC-20-REGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|