DUX4/CIC Fusion FISH Probe

Our DUX4/CIC fusion probe is designed to detect fusions between DUX4 and CIC. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: CIC encodes a high-mobility group box transcription factor, while DUX4 codes for a double homeobox transcription factor.1 Fusion of the genes results in a CIC-dominant chimera that up-regulates the PEA3 subfamily of ETS, including ETV1, ETV4, and ETV5.1 The fusion is a hallmark of undifferentiated small round cell sarcomas, affecting primarily children and young adults.2 CIC-DUX4 sarcomas are morphologically similar to Ewing sarcomas, but lack the EWSRT or TET family rearrangements specific to ES.3

*The region in which DUX4 lies is known for high levels of cross-homology with other genomic regions, which can lead to diffuse probe signals.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DUX4-CIC-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DUX4-CIC-20-GOGR 20 (40 μL) 200 μL
DUX4-CIC-20-AQGR 20 (40 μL) 200 μL
DUX4-CIC-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

Gene Details

Gene Symbol: DUX4L1

Gene Name: Double Homeobox 4 Like 1

Chromosome: CHR4: 190084411-190085695

Locus: 4q35.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.