Our FLT3 probe is designed to detect FLT3 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Gene Symbol: FLT3
Gene Name: Fms Related Tyrosine Kinase 3
Chromosome: CHR13: 28577410-28674729
FISH Probe Protocols
|Protocol, Procedure, or Form Name
There are currently no FISH related publications for this gene.