Our ETV6/RUNX1 fusion probe is designed to detect fusions between ETV6 and RUNX1. The probe comes labeled in green and orange, but can be customized to meet your needs.

Gene Background: ETV6/RUNX1 fusion is the most common genetic aberration in pediatric B-cell ALL, found in roughly 25% of patients diagnosed between the ages of 2 and 10 years.1 The fusion protein is composed of the repressor domain of ETV6 (a member of the ETS family of transcription factors) fused to RUNX1 (the DNA-binding subunit of the RUNX1/CBF beta transcription factor complex).2 It functions as a trans-dominant repressor of RUNX1-regulated target genes involved in hematopoiesis.2

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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SKU Test Kits Buffer Dye Color Order Now
ETV6-RUNX1-20-GROR  (Standard Design) 20 (40 μL) 200 μL
ETV6-RUNX1-20-GRRE 20 (40 μL) 200 μL
ETV6-RUNX1-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

Gene Details

Gene Symbol: ETV6

Gene Name: ETS Variant 6

Chromosome: CHR12: 11802787-12048325

Locus: 12p13.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Primary mammary analogue secretory carcinoma of the lung: a case report

Mammary analogue secretory carcinoma (MASC) is a type of salivary gland tumor. A rearrangement in the ETV6 gene can be characteristic of MASC, particularly fusion of ETV6-NTRK3. Our dual-color break apart probe was used to detect ETV6 translocation and aid in the diagnosis of MASC for the patient's tumor.