ETV6/RUNX1 FISH Probe
Our ETV6/RUNX1 fusion probe is designed to detect fusions between ETV6 and RUNX1. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: ETV6/RUNX1 fusion is the most common genetic aberration in pediatric B-cell ALL, found in roughly 25% of patients diagnosed between the ages of 2 and 10 years.1 The fusion protein is composed of the repressor domain of ETV6 (a member of the ETS family of transcription factors) fused to RUNX1 (the DNA-binding subunit of the RUNX1/CBF beta transcription factor complex).2 It functions as a trans-dominant repressor of RUNX1-regulated target genes involved in hematopoiesis.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ETV6-RUNX1-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|ETV6-RUNX1-20-GRRE||20 (40 μL)||200 μL|
|ETV6-RUNX1-20-REGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|