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Study on lung cancer cells express VEGFR2 and impact on the effect of RHES combined with radiotherapy in the treatment of brain metastases

2013-11-22 15:38:12

Clinical Lung Cancer; 2013 Nov 22; http://dx.doi.org/10.1016/j.cllc.2013.11.012



Xiao-dong Jiang, Man-hua Ding, Yun Qiao, Yi Liu, Liang Liu



Abstract



Background



Brain metastases (BM) is often accompanied by edema, Endostatin (ES) can prevent tumor tissue edema. Therefore, we investigated the therapeutic effects of ES combined with radiotherapy in the treatment of BM of NSCLC and discuss the relations between the effect and VEGFR2 expression.



Methods



Eighty patients with BM of NSCLC were randomly divided into combination group and radiotherapy alone group (each group with 40 patients). The short-term effective rate, overall survival time, cerebral edema index and adverse reactions were observed and the expressions of vascular endothelial growth factor receptor 2 (VEGFR2) protein and KDR gene in primary lesions were detected with immunohistochemical method and fluorescence in situ hybridization (FISH) in all patients.



Results



Compared with radiotherapy alone group, brain edema was significantly relieved (P=0.003) and there were no marked adverse reactions in combination group. In short-term effective rate, there was no statistical significance in total population (n=80, 90% vs. 75%, P=0.07), but there was statistical significance in the patients with positive VEGFR2 (93% vs. 67.7%, P=0.012) or positive KDR gene (94.4% vs. 47.3%, P=0.002) between both groups. In overall survival time, there was no statistical significance in total population (n=80, P=0.35), positive VEGFR2 patients (P=0.109) and positive KDR gene patients(P=0.147).



Conclusion



Compared with radiotherapy alone, ES combined with radiotherapy can relieve brain edema in the patients with BM of NSCLC and obtain better short-term effective rate in the patients with positive VEGFR2 or positive KDR gene, but fails to significantly improve the overall survival time.



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