Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review

2014-11-01 00:01:02

International Journal of Clinical and Experimental Pathology; 2014; 7(11):8223-8226

Min Feng, Wei Jiang, Yanmei He, Lei Li


Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the uterine cervix and discuss the clinicopathological characteristics, immunophenotype, molecular genetic feature and differential diagnosis of ASPS of cervix.


ASPS forms less than 1% of all the soft tissue sarcomas. Its histogenesis is unclear. Primary ASPS of uterine cervix is very rare. Only about 10 cases with primary involvement of the uterine cervix have been reported previously in china. It is easily misdiagnosed as other diseases, which might lead to different following therapy. Because of the rarity of the disease, to raise awareness of this disease, we reported a case and performed a detailed literature review.

Case Report

A 21-aged female, presenting with increased menstrual bleeding in 2 years duration, received treatment in our hospital 4 months ago. A hypoechoic mass occupying 3.0cm x 2.6cm x 3.4cm in cervical canal was revealed through transvaginal color doppler ultrasound, with well-defined boundary and fluent blood flow nearby. The cervical tumor resection under hysteroscope was performed. There was an exogenous 5cm x 4cm x 4cm mass near internal cervical os, with a thin pedicle. There was no abnormality in uterus corpus.

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Key Words

Alveolar soft part sarcoma | tumor | uterine cervix