Ossifying Fibromyxoid Tumor: a study of 6 cases of atypical and malignant variants2016-11-02 14:51:53
Human Pathology; 2 November 2016: DOI:10.1016/j.humpath.2016.10.012
Kossivi Dantey, MD, Karen Schoedel, MD, Oleksandr Yergiyev, MD, Richard McGough, MD, Alka Palekar, MD, Uma N.M. Rao, MD
Ossifying Fibromyxoid Tumors (OFMT) of soft parts are rare, slow growing tumors that have potential for local recurrence and may metastasize. While OFMT originally was considered benign, several cases of malignant OFMT have been documented. There is no universally accepted risk stratification, although this study emphasizes the importance of utilizing histology, immunohistochemistry and FISH in establishing the diagnosis. Herein, we describe six cases of atypical and malignant OFMT with differences in morphologic features, 5 of which display the proposed morphological criteria for malignancy. The patients were mostly male (M = 5, F = 1) with an age range of 33–69 years. The tumors arose from the extremities (3 cases), the shoulder (1 case), the head and neck area (1 case), and the paraspinal area (1 case). One tumor had high grade and overtly sarcomatous changes, while another invaded the underlying clavicle. Two cases showed cytological atypia and necrosis. Fluorescence in situ hybridization (FISH) detected rearrangement of the PHF1 gene in 5 cases. All cases were positive for EAAT4 and actin by immunohistochemistry, while negative for desmin. Three tumors were immunoreactive for S100 protein. INI-1 immunohistochemical staining was conserved in all but 2 cases in which a mosaic loss of expression was noted. All but two patients are currently alive and free of disease.
Empire Genomics PHF1 Break Apart probe labeled in Spectrum Orange-Green was used in this publication.
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