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Palisading and Verocay body-prominent dermatofibrosarcoma protuberans: a case report

2015-12-08 21:00:50

Pathology - Research and Practice; 8 December 2015: DOI:10.1016/j.prp.2015.11.020

Shuanzeng Weia, Alain Dumasb, Paul D Zhangc, Kumarasen Cooper



Abstract


Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma with a tendency for local recurrence, which commonly presents as a slowly growing flesh-colored skin lesion without epidermal invasion but with intracutaneous and subcutaneous spread. Pathologically, the tumor generally presents with an infiltrating dermal mass containing closely packed fibroblasts arranged in a storiform pattern. Several uncommon growth patterns have been described, including sclerosing, atrophic, myxoid, pigmented, giant cell-rich, granular cell, herringbone pattern and palisading/Verocay body-prominent forms. To our knowledge, only five cases of DFSP with nuclear palisading/Verocay body formation have been reported in the literature, and no t(17:22) translocation study has been done on these cases. In this report we describe such a case with negative t(17:22) translocation.



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Key Words


Dermatofibrosarcoma protuberans | Palisading | Verocay body | t(17:22) translocation