MULTICOLOR PROBE KIT
Many genetic abnormalities can develop over the course of multiple myeloma progression, starting at the premalignant stage of monoclonal gammopathy of undetermined significance (MGUS), continuing to smoldering multiple myeloma (SMM), and finally to end-stage MM. Our multiple myeloma FISH panel is made up of probes for detecting some of the most commonly encountered alterations in this genetically heterogeneous disease.
Chromosome 1 alterations are frequent in MM. On the p arm, loss of the tumor suppressor CDKN2C aids in tumor growth; on the q arm, amplification of CKS1B causes genomic breakdown.Tests: 20 Dyes:
CCND1, which helps regulate cell cycle progression, is found fused to IGH in 20% of MM cases. As with other oncogenic IGH fusions, CCND1/IGH results in overexpression of the fusion partner.Tests: 20 Dyes:
Deletions in 13q are prevalent in MM. RB1 and LAMP1 are found in two frequently deleted regions, 13q14.2 and 13q34.Tests: 20 Dyes:
MYC rearrangements are complex in MM, occurring as translocations, inversions and insertions. Studies show they could be found in up to 50% of patients.Tests: 20 Dyes:
IGH translocations are found in about 60% of MM patients, resulting in fusions with partner genes that are upregulated by IGH enhancers. Frequency of IGH fusions increases with disease stage.Tests: 20 Dyes:
Hemizygous loss of TP53 is found in just under 10% of newly diagnosed MM patients. These typically monoallelic deletions result in haploinsufficiency of this important tumor suppressor.Tests: 20 Dyes:
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Are you interested in our multicolor kit but still have questions? Send us a message with the specific probes you're interested in and we'll send you a free sample to try out.