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Many genetic abnormalities can develop over the course of multiple myeloma progression, starting at the premalignant stage of monoclonal gammopathy of undetermined significance (MGUS), continuing to smoldering multiple myeloma (SMM), and finally to end-stage MM. Our multiple myeloma FISH panel is made up of probes for detecting some of the most commonly encountered alterations in this genetically heterogeneous disease.

Copy number variations in both the p and q arms of chromosome 1 are frequent in MM. On the p arm, loss of the tumor suppressor CDKN2C aids in tumor growth; on the q arm, amplification of CDKN2C causes genomic breakdown.

Tests: 20 Dyes:

Chromosome 5 gains are recurrent in MM. They're characteristic of a hyperdiploid subtype of patients with their own unique clinical course.

Tests: 10 Dyes:

CCND1, which helps regulate cell cycle progression, is found fused to IGH in approximately 20% of MM cases. As with other oncogenic IGH fusions, CCND1/IGH results in overexpression of CCND1.

Tests: 20 Dyes:

Deletions in 13q are prevalent in MM. RB1 and LAMP1 are found in two frequently deleted regions, 13q14.2 and 13q34.

Tests: 20 Dyes:

IGH translocations are found in about 60% of MM patients, resulting in fusions with partner genes that are upregulated by IGH enhancers. Frequency of IGH fusions increases with disease stage.

Tests: 20 Dyes:

Hemizygous loss of TP53 is found in just under 10% of newly diagnosed MM patients. These typically monoallelic deletions result in haploinsufficiency of this important tumor suppressor, resulting in apoptotic resistance in tumor cells.

Tests: 20 Dyes:

Request More Information & Your Free Sample

Are you interested in our multicolor kit but still have questions? Send us a message with the specific probes you're interested in and we'll send you a free sample to try out.