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PML-RARa Fusion Probe

Our PML/RARa probe is designed to detect fusions between PML and RARA. The probe comes labeled in orange and green, but can be customized to meet your needs.

PML FISH Probe Ideogram

RARa FISH Probe Ideogram

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PML-RARA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PML

Gene Name: Promyelocytic Leukemia

Chromosome: CHR15: 74287013-74340155

Locus: 15q24.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.