IGH-MYC Full FISH Probe
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IGH-MYC Full FISH Probe
Empire Genomics has developed a IGH-MYC Full FISH probe which can be used to detect IGH and MYC gene fusions. The probe comes labeled in orange and green, and you may also choose to customize the probe to meet your needs.
*The region in which the IGH gene lies is known for high levels of cross-homology with other genomic regions. This homology can lead to diffuse probe signals.
Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Dec 2017]
Gene Symbol: IGH
Gene Name: Immunoglobulin Heavy Locus
Chromosome: CHR14: 106879843-105586436
FISH Probe Protocols
Protocol, Procedure, or Form Name
There are currently no FISH related publications for this gene.
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Williamsville, New York 14221