CCND1-IGH Split FISH Probe
Our CCND1/IGH split probe is designed to detect fusions between CCND1 and IGH. To account for the high degree of cross homology in the region containing IGH, part of the IGH portion has been removed. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: CCND1-IGH fusion is generated by t(11;14)(q13.3;q32.3), which places CCND1 gene next to IGH, resulting in constitutive overexpression of CCND1. The fusion can be found in up to 95% of patients with mantle cell lymphomas (MCL), and is considered the genetic hallmark of this subtype of low-grade peripheral B-cell neoplasms. CCND1-IGH has also been identified in other lymphoproliferative disorders (LPDs), such as B-prolymphocytic leukemia (BLL), and, less frequently, in plasma cell myelomas and B-cell chronic lymphocytic leukemia (CLL).
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|CCND1-IGH-Split-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
FISH Probe Protocols
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