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TFCP2 Break Apart FISH Probe

Empire Genomics’ TFCP2 Break Apart FISH Probe is designed to flank the TFCP2 gene and is typically used for detecting TFCP2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
TFCP2BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
TFCP2BA-20-AQOR 20 (40 μL) 200 μL
TFCP2BA-20-GOGR 20 (40 μL) 200 μL
TFCP2BA-20-GORE 20 (40 μL) 200 μL
TFCP2BA-20-GRGO 20 (40 μL) 200 μL
TFCP2BA-20-GRRE 20 (40 μL) 200 μL
TFCP2BA-20-ORGR 20 (40 μL) 200 μL
TFCP2BA-20-REGO 20 (40 μL) 200 μL
TFCP2BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

Gene Details

Gene Symbol: TFCP2

Gene Name: Transcription Factor CP2

Chromosome: CHR12: 51487538-51566926

Locus: 12q13.12-q13.13

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion

A 70 year old woman who presented with intense buttock pain that developed into a walking impairment was found to have an osteoloytic lesion in her spine, along with severe osteosclerosis. Histological and immunoreactivity analysis was performed first. Empire Genomics TFCP2 break-apart FISH probe was then used to test for TFCP2 fusions, and revealed a 64% frequency of split signals. This result prompted researchers to further analyze the tumor using reverse transcription PCR, which uncovered a novel FUS-TFCP2 fusion.
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A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

Rhabdomyosarcomas with TFCP2 fusions is an emerging family of tumors, characterized by a predilection for female patients, spindle cell morphology, and ALK overexpression. The subset also occurs most frequently in the bones, especially the craniofacial skeleton, which is very uncommon for rhabdomyosarcomas. In this study, the clinicopathological, transcriptional, and genomic features of 14 rhabdomyosarcomasa cases were evaluated. Patients were analyzed using IHC, array CGH, whole RNA-sequencing, anchored multiplex PCR-based targeted NGS, and FISH. TFCP2 translocations were detected using Empire Genomics’ TFCP2 break-apart FISH probe. TFCP2 rearrangements were found in all tested cases, fused with either EWSR1 (n = 6) or FUS (n = 8).
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Product Details

Product: TFCP2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TFCP2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping