TAF4 FISH Probe
The TAF4 FISH probe is designed to hybridize to the TAF4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TAF4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TAF4-20-RE | 20 (40 μL) | 200 μL |  |
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| TAF4-20-GO | 20 (40 μL) | 200 μL |  |
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| TAF4-20-GR | 20 (40 μL) | 200 μL |  |
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| TAF4-20-AQ | 20 (40 μL) | 200 μL |  |
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| TAF4-20-DIG | 20 (40 μL) | 200 μL |  |
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| TAF4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: TAF4
Gene Name: TATA-box Binding Protein Associated Factor 4
Chromosome: CHR20: 60549853-60640866
Locus: 20q13.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TAF4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TAF4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping