SMAD4 FISH Probe
The SMAD4 FISH probe is designed to hybridize to the SMAD4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMAD4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-RE | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-GO | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-GR | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-AQ | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-DIG | 20 (40 μL) | 200 μL |  |
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| SMAD4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: SMAD4
Gene Name: SMAD Family Member 4
Chromosome: CHR18: 48556582-48611411
Locus: 18q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SMAD4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SMAD4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping