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PTCH1 Break Apart FISH Probe

Empire Genomics’ PTCH1 Break Apart FISH Probe is designed to flank the PTCH1 gene and is typically used for detecting PTCH1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
PTCH1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
PTCH1BA-20-AQOR 20 (40 μL) 200 μL
PTCH1BA-20-GOGR 20 (40 μL) 200 μL
PTCH1BA-20-GORE 20 (40 μL) 200 μL
PTCH1BA-20-GRGO 20 (40 μL) 200 μL
PTCH1BA-20-GRRE 20 (40 μL) 200 μL
PTCH1BA-20-ORGR 20 (40 μL) 200 μL
PTCH1BA-20-REGO 20 (40 μL) 200 μL
PTCH1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]

Gene Details

Gene Symbol: PTCH1

Gene Name: Patched 1

Chromosome: CHR9: 98205263-98279247

Locus: 9q22.32

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

This study investigated various components of the tumor microenvironment (TME) in medulloblastoma, one being astrocytic differentiation. Our PTCH1/Con9 probe was used to detect PTCH1 deletion in 6 cases of SHH-activated medulloblastoma, helping to confirm that astrocytes within the tumor masses shared a common lineage with tumor cells harboring the same genetic lesion.
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Product Details

Product: PTCH1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PTCH1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping