PSTPIP1 FISH Probe
The PSTPIP1 FISH probe is designed to hybridize to the PSTPIP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PSTPIP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-RE | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-GO | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-GR | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PSTPIP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
Gene Details
Gene Symbol: PSTPIP1
Gene Name: Proline-serine-threonine Phosphatase Interacting Protein 1
Chromosome: CHR15: 77287464-77329671
Locus: 15q24.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PSTPIP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSTPIP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping