PSMC2 Break Apart FISH Probe
Empire Genomics’ PSMC2 Break Apart FISH Probe is designed to flank the PSMC2 gene and is typically used for detecting PSMC2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMC2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-GORE | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-GROR | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-REGO | 20 (40 μL) | 200 μL |
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| PSMC2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
Gene Details
Gene Symbol: PSMC2
Gene Name: Proteasome 26S Subunit, ATPase 2
Chromosome: CHR7: 102987970-103009842
Locus: 7q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PSMC2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSMC2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping